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Lorenzo A Pinna Selected Research

Protein Kinases (Protein Kinase)

10/2021Targeting CK2 in cancer: a valuable strategy or a waste of time?
3/2021Comparing the efficacy and selectivity of Ck2 inhibitors. A phosphoproteomics approach.
1/2021Contribution of the CK2 Catalytic Isoforms α and α' to the Glycolytic Phenotype of Tumor Cells.
1/2019A proteomics analysis of CK2β(-/-) C2C12 cells provides novel insights into the biological functions of the non-catalytic β subunit.
1/2015The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation.
8/2014Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential.
7/2012Structural determinants of protein kinase CK2 regulation by autoinhibitory polymerization.
12/2011Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors.
3/2010Addiction to protein kinase CK2: a common denominator of diverse cancer cells?
1/2010Assessment of CK2 constitutive activity in cancer cells.
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Lorenzo A Pinna Research Topics

Disease

46Neoplasms (Cancer)
10/2021 - 01/2003
7Cystic Fibrosis (Mucoviscidosis)
12/2018 - 07/2008
5Virus Diseases (Viral Diseases)
01/2015 - 02/2002
4Neurodegenerative Diseases (Neurodegenerative Disease)
01/2015 - 02/2002
3Neuroblastoma
01/2021 - 01/2014
3Multiple Myeloma
10/2013 - 09/2006
2Osteosarcoma (Osteogenic Sarcoma)
01/2021 - 04/2015
2Synucleinopathies
01/2014 - 02/2012
2Parkinson Disease (Parkinson's Disease)
01/2014 - 02/2012
2Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
10/2007 - 09/2003
2Lymphoma (Lymphomas)
06/2005 - 06/2005
1Infections
10/2021
1Cardiovascular Diseases (Cardiovascular Disease)
10/2021
1COVID-19
10/2021
1Shock
12/2018
1Brain Neoplasms (Brain Tumor)
11/2018
1Medulloblastoma
11/2018
1Clear Cell Adenocarcinoma
01/2018
1Glioblastoma (Glioblastoma Multiforme)
02/2017
1Myeloproliferative Disorders (Myeloproliferative Disorder)
04/2016
1Multiple Sclerosis
10/2015
1Colorectal Neoplasms (Colorectal Cancer)
06/2015
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2013
1Prostatic Neoplasms (Prostate Cancer)
02/2012
1Oncogene Addiction
02/2012
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
11/2008
1Insulin Resistance
11/2008
1Alzheimer Disease (Alzheimer's Disease)
10/2008
1Genetic Translocation (Chromosomal Translocation)
02/2008
1Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma)
02/2008
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
03/2007
1Glomerulonephritis
09/2005
1Epilepsy (Aura)
08/2005

Drug/Important Bio-Agent (IBA)

21Casein Kinase II (Casein Kinase 2)IBA
03/2021 - 03/2003
18Protein Kinases (Protein Kinase)IBA
10/2021 - 02/2002
18Phosphotransferases (Kinase)IBA
11/2020 - 01/2003
12Proteins (Proteins, Gene)FDA Link
12/2018 - 09/2003
7silmitasertibIBA
10/2021 - 01/2012
6Pharmaceutical PreparationsIBA
10/2021 - 09/2005
4Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
04/2016 - 02/2005
4EnzymesIBA
01/2014 - 02/2002
3Protein Isoforms (Isoforms)IBA
01/2021 - 09/2014
3Adenosine Triphosphate (ATP)IBA
10/2015 - 01/2013
3Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2015 - 11/2008
3Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
12/2013 - 07/2008
3beta CateninIBA
10/2007 - 09/2003
25- (3- ethynylphenylamino)pyrimido(4,5- c)quinoline- 8- carboxylic acidIBA
11/2020 - 01/2012
2SynucleinsIBA
01/2014 - 02/2012
2Casein Kinase I (Casein Kinase 1)IBA
01/2013 - 10/2008
2Peptides (Polypeptides)IBA
01/2010 - 08/2005
2DNA (Deoxyribonucleic Acid)IBA
09/2009 - 04/2004
2Emodin (Archin)IBA
07/2009 - 12/2004
2Serine (L-Serine)FDA Link
10/2008 - 03/2007
2Anaplastic Lymphoma KinaseIBA
02/2008 - 06/2005
2Tyrosine (L-Tyrosine)FDA Link
03/2007 - 06/2005
12- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA
01/2020
1cdc25 PhosphatasesIBA
01/2019
1Cadherins (E-Cadherin)IBA
01/2018
1VimentinIBA
01/2018
1Phosphates (Orthophosphate)IBA
01/2017
1TubulinIBA
06/2016
1Oncogene Proteins (Oncogene Protein)IBA
04/2016
1Cell-Penetrating PeptidesIBA
10/2015
1Fingolimod Hydrochloride (FTY720)FDA Link
10/2015
1Cyclic PeptidesIBA
10/2015
1SphingosineIBA
10/2015
1Carrier Proteins (Binding Protein)IBA
04/2015
11,2,5,8-tetrahydroxy anthraquinoneIBA
01/2015
1ProteomeIBA
01/2014
1Peptide LibraryIBA
01/2014
1CystamineIBA
01/2014
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2014
1Daunorubicin (Cerubidine)FDA LinkGeneric
10/2013
1Phenylalanine (L-Phenylalanine)FDA Link
01/2013
1NanocapsulesIBA
02/2012
1Nucleic AcidsIBA
02/2012
12- dimethylamino- 4,5,6,7- tetrabromo- 1H- benzimidazoleIBA
02/2012
1tenfibgenIBA
02/2012
1Small Interfering RNA (siRNA)IBA
02/2012
1Carboxylic AcidsIBA
10/2011
1HoloenzymesIBA
01/2010
1PhosphopeptidesIBA
09/2009
1Insulin (Novolin)FDA Link
11/2008
1Glucose (Dextrose)FDA LinkGeneric
11/2008
1PhosphoserineIBA
10/2008
1NucleotidesIBA
07/2008
1Pyridinolcarbamate (P23)IBA
02/2008
1NucleophosminIBA
02/2008
1Threonine (L-Threonine)FDA Link
03/2007
1Biological ProductsIBA
09/2005
1Cyclin-Dependent Kinases (cdk Proteins)IBA
09/2005
1RoscovitineIBA
09/2005
1kemptideIBA
08/2005
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
08/2005
1Insulin ReceptorIBA
06/2005
1Antineoplastic Agents (Antineoplastics)IBA
06/2005
1Complement System Proteins (Complement)IBA
06/2005
1Rituximab (Mabthera)FDA Link
06/2005
1src-Family KinasesIBA
02/2005

Therapy/Procedure

11Therapeutics
11/2020 - 10/2011